Endocrine Abstracts

Laron syndrome (LS) is a rare autosomal recessive genetic disorder caused by growth hormone receptor (GH-R) gene mutations, leading to congenital insulin-like growth factor-1 (IGF1) deficiency and dwarfism. Epidemiological studies have shown that there are no LS patients that suffer from cancer, which means they are protected from cancer development. While the mechanisms associated with cancer protection in LS are unknown, cancer protection might involve the insulin (INS) and ...